Reference
Combinations
A plain lookup for two substances at a time: the status the data gives that pairing, what that status means, and any note attached to it.
It reports what the dataset says and nothing beyond that. It cannot account for dose, timing, what else is in a body, or an individual medical picture — a pairing listed as lower risk is not a pairing cleared for you, and an unlisted pairing means the data is silent, not that there is nothing to know.
If a medication is part of the picture, that is a question for a prescriber or pharmacist who can see your whole history. Thesafety page has the routes.
This page keeps nothing. Your choices are not saved, not sent anywhere, and are gone when you close the tab.
Look up a pairing
Two substances, in either order. If a pairing is not in the data, it comes back as unknown rather than as safe.
Two choices above will show what the data says about that pairing.
What the statuses mean
Seven statuses, from most to least severe. The wording is ours; the categories follow the common harm-reduction taxonomy.
- Dangerous
- Considered extremely high risk. Reactions can be unpredictable and severe. Best avoided entirely.
- Unsafe
- Carries a considerable risk of physical harm. Worth avoiding where you can.
- Caution
- Not usually physically harmful, but effects can be uncomfortable or hard to predict. Care and a lower dose help.
- Low risk & decrease
- Effects tend to subtract from each other. Unlikely to add risk beyond what each carries alone.
- Low risk & no synergy
- Effects tend to add together. Unlikely to add risk beyond what each carries alone.
- Low risk & synergy
- Effects tend to amplify each other. Low risk when approached carefully; reading up first is worthwhile.
- Unknown
- Not enough reliable information to say. Worth treating as unpredictable.
TripSit combination chart · community-maintained · snapshot 2026-08-21 · taxonomy reference